Seth A Darst Selected Research

DNA-Directed RNA Polymerases (RNA Polymerase)

1/2020	Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.
1/2018	Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts.
1/2017	Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
1/2017	Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex.
10/2012	Initiation of transcription-coupled repair characterized at single-molecule resolution.

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Seth A Darst Research Topics

Disease

7	Tuberculosis (Tuberculoses) 12/2020 - 02/2005
4	Infections 01/2020 - 01/2011
1	COVID-19 12/2021
1	Communicable Diseases (Infectious Diseases) 12/2020
1	Cystic Fibrosis (Mucoviscidosis) 01/2020
1	Superinfection 01/2017
1	Starvation 10/2012

Drug/Important Bio-Agent (IBA)

5	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2020 - 10/2012
3	Rifampin (Rifampicin)FDA LinkGeneric 12/2020 - 02/2005
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 10/2012
1	Synthetic DrugsIBA 12/2021
1	Antiviral Agents (Antivirals)IBA 12/2021
1	Complement System Proteins (Complement)IBA 12/2021
1	Bacterial RNAIBA 10/2018
1	RifamycinsIBA 10/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2018
1	HoloenzymesIBA 01/2018
1	FidaxomicinIBA 01/2018
1	16S Ribosomal RNAIBA 01/2017
1	NucleotidesIBA 10/2012
1	Proteins (Proteins, Gene)FDA Link 01/2011
1	Rifabutin (Ansamycin)FDA Link 02/2005

Therapy/Procedure

1	Therapeutics 12/2021